Skip to content

Choline Dihydrogen Phosphate Synthesis Essay


Some ionic liquids (ILs) possess negligible vapor pressure as well as fascinating features such as high thermal, chemical and electrochemical stability. ILs have gained increasing attention as green, multi-use reaction media as well as solvents for a electrochemistry and chemistry (Welton, 1999; Seddon, 1997; Wasserscheid & Welton, 2002). ILs are also currently being investigated for a variety of bio-applications including media for biocatalytic reactions (van Rantwijk et al., 2003; Zhao et al., 2008), biosensors (Ohno, 2005) and protein stabilization (Fujita et al., 2005; Byrne et al., 2007). We have been studying hydrated IL as solvents for proteins. We have already reported that some proteins are soluble, stable, and remain active in some hydrated ILs. For example, the title compounds, acts as an excellent preserver of proteins such as cytochrome c.

The title compound (I) consists of cations and anions. The molecular structures of (I) are shown in Fig. 1. Two hydrogen bonds of O4—H···O2 connect anions and construct dimer along the b axis (Fig. 2). The dimers are connected with each other by the two hydrogen bonds of O5—H···O1 and O3—H···O5, through the hydroxyl group (Table 1). These hydrogen bonds create a columnar structure of anions and cations along the a axis. The columnar structures interact with each other by C—H···O hydrogen bond and van der Waals forces (Table 1).

Hydrogen-bond geometry (Å, °)

Symmetry codes: (i) −x+2, −y+1, −z; (ii) −x+1, −y+1, −z; (iii) −x+1, −y+1, −z+1; (iv) x, y−1, z.

O3—H3O···O5i0.80 (4)1.79 (4)2.586 (3)178 (3)
O4—H4O···O2i0.93 (4)1.60 (4)2.526 (2)173 (3)
O5—H5O···O1ii0.93 (4)1.63 (4)2.556 (3)176 (4)
C3—H3B···O10.982.483.439 (3)166
C4—H4B···O3iii0.982.543.504 (3)170
C4—H4C···O1iv0.982.493.457 (3)168
C5—H5A···O3iv0.982.463.430 (3)172
C5—H5B···O1iii0.982.423.382 (3)169
C5—H5C···O20.982.603.549 (3)164

Citation data is made available by participants in Crossref's Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search inSciFinder.

  • Choline-Based Amino Acid ILs–Collagen Interaction: Enunciating Its Role in Stabilization/Destabilization Phenomena

    AafiyaTarannumJ. RaghavaRaoN. NishadFathima

    The Journal of Physical Chemistry B2018122 (3), 1145-1151

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Impact of Ionic Liquids on the Structure and Dynamics of Collagen

    AafiyaTarannumAlinaAdamsBernhardBlümichNishter NishadFathima

    The Journal of Physical Chemistry B2018122 (3), 1060-1065

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Integrated Depilation and Fiber Opening Using Aqueous Solution of Ionic Liquid for Leather Processing

    Jaya PrakashAllaJonnalagadda RaghavaRaoNishter NishadFathima

    ACS Sustainable Chemistry & Engineering20175 (10), 8610-8618

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Role of Preferential Ions of Ammonium Ionic Liquid in Destabilization of Collagen

    AafiyaTarannumCharuvakaMuvvaAmiMehtaJ.Raghava RaoN. NishadFathima

    The Journal of Physical Chemistry B2016120 (27), 6515-6524

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Ionic Liquids for the Synthesis and Design of Hybrid Biomaterials and Interfaces

    Rui F. P.PereiraKerstinZehbeStefanieKrügerMaria M.SilvaAhmedSalamaPeterHesemannVeronicade Zea BermudezAndreasTaubert


  • Exploiting oleuropein for inhibiting collagen fibril formation

    H.BharathyN. NishadFathima

    International Journal of Biological Macromolecules2017101, 179-186

  • Influence of cholinium-based ionic liquids on the structural stability and activity of α-chymotrypsin


    New Journal of Chemistry201741 (22), 13902-13911

  • Piezoelectric poly(lactide) stereocomplexes with a cholinium organic ionic plastic crystal

    P.BarbosaJ.CamposA.TuryginV. Y.ShurA.KholkinA.Barros-TimmonsF. M.Figueiredo

    Journal of Materials Chemistry C20175 (46), 12134-12142

  • Phosphonium based ionic liquids-stabilizing or destabilizing agents for collagen?

    AafiyaTarannumCharuvakaMuvvaAmiMehtaJ. RaghavaRaoN. NishadFathima

    RSC Adv.20166 (5), 4022-4033